To Play The Cancer Game in Windows 10, you'll have to use Microsoft Internet Explorer instead of Microsoft Edge. You can start Internet Explorer from the Start Menu > All Programs > Internet Explorer.

Once Internet Explorer is open, head to Adobe to download the free Shockwave software. I suggest you uncheck any free add-ons.

Make Sure you have The Cancer Game added to your Favorites so you can return to the game after the plug-in installs.

Return to The Cancer Game web site after Shockwave installs, and click "Play The Game."